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Lab testing for difluoroethane is seldom done, partly because the maximum detection time (MDT) is unknown. 1,1-Difluoroethane abuse is reported to be potentially fatal and to cause acute and chronic adverse health effects. (1) Background: Inhalant abuse and misuse are still widespread problems. Though not specific to DFE abuse, inhalant abusers in general have higher rates of major depression, suicidal ideation and attempts, and other substance use disorders than nonusers of inhalants. Some reported long-term health effects include skeletal fluorosis and possibly chronic kidney disease. Reported acute health effects of DFE inhalation in nonfatal cases include auditory and visual hallucinations and delusions, mania with psychosis, disorientation, poor judgement and disinhibition, tremors, ataxia, generalized tonic clonic seizure activity, dyspnea on exertion, pulmonary irritation and cough, frostbite burns of skin, cutaneous burn injury by hydrofluoric acid from thermal degradation of DFE, cutaneous flame burns from fire ignition of DFE, angioedema, palpitations and irregular pulse, chest pain, pneumopericardium, cardiomyopathy, toxic myocarditis, nausea and vomiting, acute liver injury and fulminant hepatitis, rhabdomyolysis and acute renal failure. The Florida State Medical Examiners Commission found that there were 49 statewide deaths caused by inhalants in 2018 of which 83% involved halogenated inhalants, especially DFE.